What is pellagra?

Pellagra is a disease that affects your digestive system, skin, and nerves, resulting in dermatitis, diarrhea, and mental disorders. The most common cause of pellagra is not having enough niacin (primary pellagra). Other causes of pellagra are associated with digestive disorders that reduce the absorption of niacin in your body.

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Niacin is also known as nicotinic acid, or vitamin B3. In the United States, individuals most at risk for developing pellagra are alcoholics, as a result of malnutrition.

Both alcoholism and not consuming enough green vegetables, seafood, meat, and eggs commonly cause primary pellagra. Secondary pellagra occurs when sufficient niacin is consumed but not taken up and used by the body. Secondary pellagra is often caused by gastrointestinal diseases that prevent absorption of niacin. Because tryptophan is needed to make niacin, low levels of tryptophan may also lead to pellagra.

The signs and symptoms of pellagra can be constant or occur periodically. Pellagra varies among individuals. Some people with pellagra have mild symptoms, such as fatigue, while others may develop severe depression and anxiety. Fortunately, pellagra can be treated with nutritional supplementation to resolve deficiencies in niacin. Lifestyle changes can reduce your risk for pellagra and include limiting alcohol intake, eating a well-balanced diet, not smoking, and always taking all medications and supplements as prescribed.

In some cases, if left untreated, pellagra can lead to dementia, anxiety or depression that should be immediately evaluated in an emergency setting. Seek immediate medical care (call 911) if you, or someone you are with, have any of these serious symptoms, including altered mental status, alcohol withdrawal, or severe depression with suicidal thoughts.

Seek prompt medical care if you are being treated for pellagra but mild symptoms recur or are persistent.

SYMPTOMS

What are the symptoms of pellagra?

Pellagra is a condition of having too little niacin in the body and affects the normal function of the nerves, digestive system, and skin. Pellagra may result in a number of symptoms. The symptoms can vary in intensity from person to person.... Read more about pellagrasymptoms

CAUSES

What causes pellagra?

The most common cause of pellagra is inadequate intake of the B vitamin known as niacin (primary pellagra). The most typical cause of primary pellagra is not consuming enough green vegetables, seafood, meat, and eggs. Alcoholism is commonly associated with pellagra as the result of malnutrition.... Read more about pellagracauses

TREATMENTS

How is pellagra treated?

Treatment for pellagra begins with seeking medical care from your health care provider. To determine whether you have pellagra, your health care provider will ask you questions, request a blood sample, and possibly prescribe diagnostic testing. It is important to follow your treatment plan for pellagra precisely and to take all medications as instructed.... Read more about pellagratreatments

Medical Reviewer: All content has been reviewed by board-certified physicians under the direction of Rich Klasco, M.D., FACEP. Last Annual Review Date: May 2, 2011 Copyright: © Copyright 2011 Health Grades, Inc. All rights reserved. May not be reproduced or reprinted without permission from Health Grades, Inc. Use of this information is governed by the HealthGrades User Agreement.

This Article is Filed Under: Digestive System


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