What causes gigantism?

Gigantism is caused by an overproduction of growth hormone (GH) that occurs in childhood before the bone growth plates have closed. Diseases, disorders and conditions that can cause GH overproduction leading to gigantism include:

  • Benign tumors of the pituitary gland, which press on the pituitary gland and cause excessive GH production. This is the most common cause of gigantism.
  • Carney complex (rare gene mutation that causes a high risk of certain tumors including pituitary adenoma)
  • McCune-Albright syndrome (syndrome caused by a gene mutation)
  • Multiple endocrine neoplasia type 1 (inherited disorder that causes tumors to form in endocrine glands and makes them hyperactive)
  • Neurofibromatosis (genetic disorder causing tumor growth)

What are the risk factors for gigantism?

Gigantism is a very rare disorder. The main risk factor for gigantism is having a parent or sibling with gigantism.


What is gigantism?

Gigantism is a very rare condition that occurs during childhood, in which there is extreme bone, muscle and organ growth. Gigantism is caused by an overproduction of growth hormone (GH) that occurs before a child’s bone growth plates have closed. This results in excessive growth and abnormally tall height.... Read more about gigantismintroduction


What are the symptoms of gigantism?

Gigantism is characterized by extreme growth. Children with gigantism are very tall for their age and may also have the following conditions:


How is gigantism treated?

Treatment of gigantism may involve a combination of techniques to reduce or regulate the pituitary gland’s release of growth hormone (GH). The exact treatment plan will vary based on the underlying cause of the overproduction of GH. Your healthcare provider is best able to guide your treatment decisions based on your specific circumstances.

Medical treatments of gigantism

... Read more about gigantismtreatments

Medical Reviewer: William C. Lloyd III, MD, FACS Last Annual Review Date: Aug 23, 2013 Copyright: © Copyright 2014 Health Grades, Inc. All rights reserved. May not be reproduced or reprinted without permission from Health Grades, Inc. Use of this information is governed by the HealthGrades User Agreement.

This Article is Filed Under: Bones, Joints and Muscles

What's Causing Your Symptoms?