How is duodenitis treated?

Treatment for duodenitis begins with seeking medical care from your health care provider. To determine if you have duodenitis, your health care provider may ask you to provide blood, urine, and stool samples for laboratory tests. Upper endoscopy permits visualization of the duodenum and the collection of small mucosal biopsies. Biopsies are studied under the microscope to confirm H pylori infection.

Antibiotic treatments for duodenal ulcer

If your duodenitis is caused by H pylori infection, antibiotic therapy is the mainstay of treatment. It is important to follow your antibiotic regimen precisely to avoid re-infection or recurrence. Most commonly, two antibiotics are given for 14 days. Examples of antibiotic treatments include:

  • Amoxicillin
  • Clarithromycin (Biaxin)
  • Metronidazole (Flagyl)
  • Tetracycline

Other medications to treat duodenitis

Medications such as proton pump inhibitors and histamine H2-receptor antagonists, which decrease the amount of acid in the stomach, can also be an effective treatment for duodenitis.

Proton pump inhibitors that may be effective in the treatment of duodenitis include:

  • Esomeprazole (Nexium)
  • Lansoprazole (Prevacid)
  • Omeprazole (Prilosec)
  • Pantoprazole (Protonix)
  • Rabeprazole (Aciphex)

Histamine H2-receptor antagonists that may be effective in the treatment of duodenitis include:

  • Cimetidine (Tagamet)
  • Famotidine (Pepcid)
  • Nizatidine (Axid)
  • Ranitidine (Zantac)

If you have diarrhea and vomiting, fluid and electrolyte replenishment is also a component of successful treatment.

What are the potential complications of duodenitis?

You can help minimize your risk of serious complications by following the treatment plan you and your health care professional design specifically for you. Complications of duodenitis include:

  • Abdominal wall inflammation
  • Internal hemorrhaging
  • Instinal obstruction
  • Perforated peptic ulcer (bleeding stomach or intestinal ulcer)
  • Recurrent duodenal ulcers (even after eradication of H pylori infection)
  • Secondary pancreatitis


  1. Duodenitis. Krames Patient Education.,S,40530.
  2. Rustagi T, Rai M, Scholes JV. Collagenous gastroduodenitis. J Clin Gastroenterol. 2011 Feb 22. [Epub ahead of print].
  3. Tierney LM Jr., Saint S, Whooley MA (Eds.) Current Essentials of Medicine (4th ed.). New York: McGraw-Hill, 2011.

What is duodenitis?

Duodenitis is inflammation occurring in the duodenum, the beginning of the small intestine. Inflammation in the lining of the duodenum may result in abdominal pain, bleeding, and other gastrointestinal symptoms. The most common cause of duodenitis is a stomach infection associated with a type of bacteria called Helicobacter pylori (H pylori). This organism disrupts the mucus barrier that n... Read more about duodenitisintroduction


What are the symptoms of duodenitis?

Duodenitis causes inflammation of the stomach lining that may result in a number of symptoms. The symptoms can vary in intensity among individuals.

Common symptoms of duodenitis

You may experience duodenitis symptoms daily or just once in a while. At times any of these abdominal symptoms can be severe:


What causes duodenitis?

The most common cause of duodenitis is H pylori infection. Other causes of duodenitis include prolonged use of medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), which can cause inflammation of the lining of the duodenum. Severe illness, radiation therapy, and Crohn’s disease are also associated with duodenitis.

What are the risk factors for duodenitis?

... Read more about duodenitiscauses

Medical Reviewer: William C. Lloyd III, MD, FACS Last Annual Review Date: Aug 9, 2013 Copyright: © Copyright 2014 Health Grades, Inc. All rights reserved. May not be reproduced or reprinted without permission from Health Grades, Inc. Use of this information is governed by the HealthGrades User Agreement.

This Article is Filed Under: Digestive System

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