Chronic Inflammatory Demyelinating Polyneuropathy

What is chronic inflammatory demyelinating polyneuropathy?

Chronic inflammatory demyelinating polyneuropathy (CIPD) is a condition that arises when the myelin sheaths around nerve cells are damaged. Myelin, the insulating layer of tissue that surrounds nerve cells, helps ensure that signals from the brain are rapidly transmitted to the proper places in the body. When myelin is damaged or destroyed, it can lead to problems with communication between the brain and the body. In CIPD, this manifests as muscle weakness and impaired motor control.

In CIPD the nerves are chronically swollen and irritated. This inflammation damages peripheral nerves, but not the brain or spinal cord. While CIPD is sometimes associated with inflammatory or autoimmune conditions, the exact cause is not known.

Symptoms of CIPD include impaired motor control, general weakness, and impaired sense of touch. As the condition progresses, it can lead to muscle atrophy and spasms; difficulty swallowing, chewing and talking; impaired coordination; and even paralysis.

In some cases, CIPD can be treated. By controlling inflammation, it may be possible to slow or stop the progression of the disease and alleviate symptoms. Treatments for CIPD include the use of steroids, immunosuppressant drugs, or immunotherapy. Removing antibodies that attack the nerve cells using a technique called plasmapheresis can benefit some patients. Left untreated, CIPD can lead to permanent neurological damage.

Seek immediate medical care (call 911) for serious symptoms of nerve damage, such as paralysis or inability to move a body part, and breathing problems.

Seek prompt medical care if you are being treated for CIPD and your symptoms worsen or begin to interfere with your daily life.


What are the symptoms of chronic inflammatory demyelinating polyneuropathy?

Symptoms of chronic inflammatory demyelinating polyneuropathy (CIPD) are related to the breakdown of myelin (nerve cell insulation). These symptoms are progressive and may begin with minor weakness, changes in sensation, or impaired motor control.

Early symptoms of CIPD

Early symptoms of CIPD are related to inflammation of the nerves. You may experience CIPD symptoms da... Read more about chronic inflammatory demyelinating polyneuropathysymptoms


What causes chronic inflammatory demyelinating polyneuropathy?

In many cases, the exact cause of chronic inflammatory demyelinating polyneuropathy (CIPD) is not known. It may occur with other conditions, including some autoimmune disorders and inflammatory diseases.

Conditions that may be linked to chronic inflammatory demyelinating polyneuropathy

Diseases and disorders associated with CIPD include:


How is chronic inflammatory demyelinating polyneuropathy treated?

Treatment for chronic inflammatory demyelinating polyneuropathy (CIPD) is aimed at controlling symptoms and slowing the progression of the disease. Early diagnosis and treatment for CIPD is important, as proper treatment may halt, or even completely reverse, CIPD.

Medications for CIPD

Medication for CIPD is designed to reduce inflammation and prevent the immune system f... Read more about chronic inflammatory demyelinating polyneuropathytreatments

Medical Reviewer: William C. Lloyd III, MD, FACS Last Annual Review Date: Aug 9, 2013 Copyright: © Copyright 2014 Health Grades, Inc. All rights reserved. May not be reproduced or reprinted without permission from Health Grades, Inc. Use of this information is governed by the HealthGrades User Agreement.

This Article is Filed Under: Brain and Nerves